Synthesis of Nitrogen Functional Derivatives of 5-substituted-6-azauracil as one of the Four Nucleobases in the Nucleic Acid of RNA

Authors

  • E. Amereh
  • L. Torkian
  • N. Mohammadi
Abstract:

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoateshave been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides.Reactions ofthe 3-arylhydrazono-2,4-dioxo-4-phenylbutanoateswith 1-aminoguanidine, semicarbazide, and thiosemicarbazidegave5-substituted 2-imino-6-azauracil (3a),6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds - IR, 1H, and 13C NMR spectral data - are reported.

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Synthesis of Some Nitrogen Functional Derivatives of 5-substituted-6-azauracil as Biologically Active Compounds

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoates have been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides. Reactions of the 3-arylhydrazono-2,4- dioxo-4-phenylbutanoates with 1-aminoguanidine, semicarbazide, and thiosemicarbazide gave 5-substituted 2-imino-6-azauracil (3a), 6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds ...

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Journal title

volume 6  issue 2

pages  78- 84

publication date 2015-11-17

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